L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- → HCID 71105111, 화합물

HRID 242387

반응식

HRID 242387 반응식
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:16](=[O:18])[CH3:17])[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[CH:7]=1.[NH:19]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:20]([C:25]([OH:27])=O)[CH2:21][CH:22]([CH3:24])[CH3:23].CCN=C=N[CH2:40][CH2:41][CH2:42]N(C)C.Cl>ClCCl.CN(C1C=CN=CC=1)C>[C:16]([C:5]1[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:13])[CH3:15])[CH:7]=[C:3]([CH2:2][O:1][C:25](=[O:27])[C@@H:20]([NH:19][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:21][C:22]2[CH:23]=[CH:42][CH:41]=[CH:40][CH:24]=2)[N:4]=1)(=[O:18])[CH3:17]

참가 물질

6

반응물 3

HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 710869721-(4-hydroxymethyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-2-yl)ethanone

생성물 1

HCID 71105111HCID 71105111, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

The compound (2.00 g) obtained in (3) was dissolved in dichloromethane (10 mL), and Boc-Leu-OH (2.21 g), EDC.HCl (2.13 g), and DMAP (0.99 g) were added while stirring. After the stirring was continued for 1 day, the solvent was distilled off under reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%) using silica gel column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation) to afford the title compound (3.20 g).

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%)

출처 및 근거

ORD 기록
ord-ee60c6e8bc1744969018dda8e777ca7c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653126B2

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