Thionyl Chloride → Hydrochloric Acid

HRID 24287

반응식

HRID 24287 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6](CO)[CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:15])=O>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:15]

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 27638232-Hydroxy-5-nitrobenzyl alcohol

생성물 2

HCID 313Hydrochloric AcidHCID 9804-Nitrophenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The 4-nitro-2-hydroxymethylphenol is then converted to a 2-halomethyl-4-nitrophenol via a mild halogenation reaction such as a thionyl chloride in THF or is produced directly from 4-nitrophenol in a solution of concentrated HCl, a catalytic amount of H2SO4 and formaldehyde dimethylacetal solution by bubbling gaseous HCl through the solution at about 50 to 80° C. (preferably 70° C.) until a thick white precipitate is formed. The thionyl chloride conversion of the 2-hydroxymethyl group is shown process is shown as follows:

출처 및 근거

ORD 기록
ord-0bc3368c4db74dd88c16b51853f605b4
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855833B2

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