Potassium Cyanide → Ethyldiisopropyl-ammonium

HRID 24290

반응식

HRID 24290 반응식
[CH2:1]=[C:2]1[CH:8]2[CH2:9][CH:5]([CH2:6][CH2:7]2)[C:4](=[O:10])[O:3]1.[CH3:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15].[C-]#N.[K+]>C(#N)C>[CH2:12]([NH+:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[CH3:11].[OH:3][C:2]1[CH:8]2[CH2:9][CH:5]([CH2:6][CH2:7]2)[C:4](=[O:10])[CH:1]=1

참가 물질

6

반응물 3

HCID 9032Potassium CyanideHCID 81531DiisopropylethylamineHCID 129939774-Methylene-3-oxabicyclo[3.2.1]octan-2-one

생성물 2

HCID 3411517Ethyldiisopropyl-ammoniumHCID 129939804-Hydroxybicyclo[3.2.1]oct-3-en-2-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Analogously to Example P1, 1.38 g (10 mmol) of 4-methylene-3-oxabicyclo[3.2.1]octan-2-one are stirred over a period of 12 hours in the presence of 1.29 g (10 mmol) of Hünig's base and 0.13 g of potassium cyanide in 10 ml of acetonitrile. Solid components (potassium salts) are filtered off and the filtrate is evaporated to dryness to yield the ethyldiisopropyl-ammonium salt of 4-hydroxybicyclo[3.2.1]oct-3-en-2-one in the form of a resin.

후처리

  1. filtrationSolid components (potassium salts) are filtered off
  2. customthe filtrate is evaporated to dryness

출처 및 근거

ORD 기록
ord-db5741c94adc43d09fa3ea6ec262eab3
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855831B2

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