Hydrochloric Acid → 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid

HRID 244648

반응식

HRID 244648 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Na+].Cl.O>C(O)C>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate

생성물 1

HCID 288755572-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (278 mg) in ethanol (3.5 ml) was added 2M sodium hydroxide solution (2.4 ml) and the mixture stirred at RT for 1 h. The mixture was acidified by the addition of 2M hydrochloric acid solution (2.5 ml) and the mixture blown to dryness. The residue was treated with water (2 ml) and extracted with ethyl acetate (3×5 ml). The combined organic extracts were dried over sodium sulphate and evaporated to give the title compound (168 mg) as a beige solid.

후처리

  1. extractionextracted with ethyl acetate (3×5 ml)
  2. dry with materialThe combined organic extracts were dried over sodium sulphate
  3. customevaporated

출처 및 근거

ORD 기록
ord-5673697bba6c4e48a09a55bfc1aef75d
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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