Hydrochloric Acid → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

HRID 244687

반응식

HRID 244687 반응식
[OH-].[Li+].C1COCC1.[CH3:8][N:9]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([O:17]C)=[O:16])=[N:10]1.Cl>O>[CH3:8][N:9]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([OH:17])=[O:16])=[N:10]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 20718566methyl 1,4-dimethyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Lithium hydroxide (0.864 g), THF (30 ml) and water (30 ml) were added to methyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (1.39 g) and the reaction was stirred at room temperature for 3 h. The reaction was acidified with 5M HCl (aq) to pH to 7 and then washed through a waters HLB OASIS cation exchange cartridge. The cartridge was preconditioned with methanol, then water. The reaction was loaded onto the cartridge and washed with water, then eluted with methanol. The methanol fraction was evaporated in vacuo to give title compound, 1.1 g.

후처리

  1. washwashed through a waters HLB OASIS cation exchange cartridge
  2. washwashed with water
  3. washeluted with methanol
  4. customThe methanol fraction was evaporated in vacuo

출처 및 근거

ORD 기록
ord-96d268033c7b46709567f9bdc6904a32
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

연결된 노트

불러오는 중…