Hydrochloric Acid → 4-Hydroxymethyl-N-(2-methoxyphenyl)benzenesulfonamide

In an atmosphere of argon and with cooling in an ice bath, 4-[(2-methoxyanilino)sulfonyl]benzoic acid (150 mg, 0.488 mmol) was dissolved in THF (5 ml), to which were subsequently added dropwise triethylamine (0.14 ml, 1.0 mmol) and ethyl chloroformate (50 μl, 0.509 mmol). After 30 minutes of stirring at the same temperature, the thus formed precipitate was removed by filtration, and the resulting filtrate was concentrated. The thus obtained residue was dissolved in 5 ml of THF, and, with cooling in an ice bath, sodium borohydride (46.5 mg, 1.22 mmol) and water (1 ml) were added to the resulting solution. After 40 minutes of stirring at the same temperature, the reaction mixture was adjusted to pH 4 to 5 with 2N hydrochloric acid and extracted with ether. The organic layer was washed with saturated brine and dried on anhydrous magnesium sulfate. After removing the solvent by evaporation, the resulting colorless oily material was purified by silica gel column chromatography (ether) to obtain 99.6 mg (69.6%) of the title compound in the form of colorless solid.

1. temperatureIn an atmosphere of argon and with cooling in an ice bath
2. customthe thus formed precipitate was removed by filtration
3. concentrationthe resulting filtrate was concentrated
4. dissolutionThe thus obtained residue was dissolved in 5 ml of THF
5. temperaturewith cooling in an ice bath
6. stirringAfter 40 minutes of stirring at the same temperature
7. extractionextracted with ether
8. washThe organic layer was washed with saturated brine
9. dry with materialdried on anhydrous magnesium sulfate
10. customAfter removing the solvent
11. customby evaporation
12. customthe resulting colorless oily material was purified by silica gel column chromatography (ether)

ORD 기록

ord-5fabbe4482ff451aa260f688512ff2dd

출처 데이터셋

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05728835