Acetic Anhydride → L-Phenylalanine, methyl ester

HRID 24638

반응식

HRID 24638 반응식
OC(C(F)(F)F)=O.[CH3:8][O:9][C:10](=[O:37])[C@H:11]([CH2:23][C:24]1[CH:29]=[CH:28][C:27](C2C=CC=CC=2N)=[CH:26][CH:25]=1)[NH:12]C(=O)C1C(Cl)=CC=CC=1Cl.CC(OC(C)=O)=O.CCN(C(C)C)C(C)C.CCOC(C)=O>C1COCC1>[CH3:8][O:9][C:10](=[O:37])[C@H:11]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:12]

참가 물질

6

반응물 4

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 131723775N-(2,6-dichlorobenzoyl)-4-(2-aminophenyl)-L-phenylalanine methyl ester TFA salt

생성물 1

HCID 736234L-Phenylalanine, methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-(2,6-Dichlorobenzoyl)-4-(2-aminophenyl)-L-phenylalanine methyl ester TFA salt (90 mg) was dissolved in dry THF (5 mL). Ac2O (60 μL) and DIEA (160 μL) were added and the mixture was stirred at room temperature for 12 h. EtOAc was added and the resulting mixture was extracted with water. The organic phase was dried (MgSO4) and evaporated to give N-(2,6-dichlorobenzoyl)-4-[2-(acetylamino)]phenyl]-L-phenylalanine methyl ester.

후처리

  1. extractionthe resulting mixture was extracted with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-1434c017a5c64fb6b877dce0c0b7ee4c
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855843B2

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