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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-(2-cyclopropylpropan-2-yl)-2-(6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

HRID 246684
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HRID 246684 반응식
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[N:12]=[C:13]4[C:19]([C:20]([OH:22])=O)=[CH:18][NH:17][C:14]4=[N:15][CH:16]=3)=[N:7][NH:8]2)=[CH:4][CH:3]=1.CCN=C=NCCCN(C)C.CCN(C(C)C)C(C)C.Cl.[CH:44]1([C:47]([NH2:50])([CH3:49])[CH3:48])[CH2:46][CH2:45]1>CN(C1C=CN=CC=1)C.CN(C=O)C.O>[CH:44]1([C:47]([NH:50][C:20]([C:19]2[C:13]3[C:14](=[N:15][CH:16]=[C:11]([C:6]4[C:5]5[C:9](=[CH:10][C:2]([CH3:1])=[CH:3][CH:4]=5)[NH:8][N:7]=4)[N:12]=3)[NH:17][CH:18]=2)=[O:22])([CH3:49])[CH3:48])[CH2:46][CH2:45]1
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참가 물질

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반응물 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 677456142-Cyclopropylpropan-2-amine hydrochlorideHCID 712798942-(6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

생성물 1

HCID 71280555N-(2-cyclopropylpropan-2-yl)-2-(6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide수율 9.4%

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine촉매HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 2-(6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (100 mg, 0.34 mmol), EDCI (130 mg, 0.68 mmol), DMAP (83 mg, 0.68 mmol) and DIEA (88 mg, 0.68 mmol) in 6 mL of DMF was added 2-cyclopropylpropan-2-amine hydrochloride (92 mg, 0.68 mmol) in one portion at room temperature, then the mixture was stirred for 16 hours. The reaction mixture was poured into 40 mL of water, filtered and the filter cake was purified by preparative-HPLC (Gemini 5u C18 150×21.2 mm; inject volume: 3 mL/inj, flow rate: 20 mL/min; wavelength: 214 nm and 254 nm; the gradient conditions were: 45% acetonitrile/55% water (0.1% trifluoroacetic acid, v/v) initially, proceeding to 75% acetonitrile/25% water (0.1% trifluoroacetic acid, v/v) in a linear fashion over 9 min.) to give N-(2-cyclopropylpropan-2-yl)-2-(6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (12 mg, 9.4%) as a yellow solid. MS: (M+H)+=375; 1H NMR (300 MHz, DMSO): δ 13.38 (s, 1H), 12.80 (s, 1H), 9.16 (s, 1H), 8.41-8.35 (m, 2H), 7.95 (s, 1H), 7.41 (s, 1H), 7.06 (d, 1H, J=8.4 Hz), 2.57 (s, 3H), 1.67-1.54 (m, 1H), 1.59 (s, 6H), 0.48-0.44 (m, 4H).

후처리

  1. filtrationfiltered
  2. customthe filter cake was purified by preparative-HPLC (Gemini 5u C18 150×21.2 mm
  3. wait45% acetonitrile/55% water (0.1% trifluoroacetic acid, v/v) initially, proceeding to 75% acetonitrile/25% water (0.1% trifluoroacetic acid, v/v) in a linear fashion over 9 min.

출처 및 근거

ORD 기록
ord-eb251c35f32a44bcb4cf9a2122d22b0e
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08658646B2

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