Sodium hydride → 6-[5-(4-Chlorobenzyl)-thien-2-yl]-hex-5-enoic acid
반응식
[H-].[Na+].[Br-].[OH:4][C:5]([CH2:7][CH2:8][CH2:9][CH2:10][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:6].[Cl:30][C:31]1[CH:44]=[CH:43][C:34]([CH2:35][C:36]2[S:40][C:39]([CH:41]=O)=[CH:38][CH:37]=2)=[CH:33][CH:32]=1>CS(C)=O>[Cl:30][C:31]1[CH:44]=[CH:43][C:34]([CH2:35][C:36]2[S:40][C:39]([CH:41]=[CH:10][CH2:9][CH2:8][CH2:7][C:5]([OH:6])=[O:4])=[CH:38][CH:37]=2)=[CH:33][CH:32]=1참가 물질
5
실험 절차
This compound is prepared analogously to Example 7b from: 6.3 g of sodium hydride (=7.8 g of 80% strength mineral oil suspension) in 180 ml of dimethylsulphoxide, 57.9 g of 4-hydroxycarbonylbutyl-triphenylphosphonium bromide in 180 ml of dimethylsulphoxide and 25.0 g of 5-(4-chlorobenzyl)-thiophene-2-aldehyde in 20 ml of dimethylsulphoxide.