Kojic Acid → 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one
반응식
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].[OH-].[Na+].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CO.O>[CH2:13]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
5
실험 절차
To a stirred solution of 17 g (0.12 mole) of kojic acid and 5.1 g (0.13 mole) of sodium hydroxide in 190 ml of 10:1 (by volume) methanol-water was added dropwise 17.5 g (0.14 mole) of benzyl chloride. After 4.5 hours at reflux, the mixture was allowed to cool and was poured into 200 ml of ice-water. The resultant solid was collected, washed with water, and dried, giving 22.4 g of analytically pure title compound, m.p. 128°-130°.
후처리
- temperatureAfter 4.5 hours at reflux
- temperatureto cool
- customThe resultant solid was collected
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-332fa967a5b1494198ad8a61e36c51af
- 출처 데이터셋
- uspto-grants-1987_11
- 특허 번호
- US04705871
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