Hydrochloric Acid → 1-(Chloromethyl)-4-Ethoxybenzene

HRID 247243

반응식

HRID 247243 반응식
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8]O)=[CH:6][CH:5]=1)[CH3:2].[ClH:12]>>[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:12])=[CH:6][CH:5]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 803454-Ethoxybenzyl alcohol

생성물 1

HCID 20639711-(Chloromethyl)-4-Ethoxybenzene

실험 절차

4-Ethoxybenzyl alcohol (5 g) and concentrated hydrochloric acid (8.5 cm3) were vigorously stirred together for 30 minutes. The 2 phases were then allowed to separate, and the lower layer separated off, and diluted with chloroform. The organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation gave 4-ethoxybenzyl chloride (5.6 g). (This product is not stable on keeping, so was converted immediately to the phosphonium salt--see Example 12).

후처리

  1. customto separate
  2. customthe lower layer separated off
  3. additiondiluted with chloroform
  4. dry with materialThe organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation

출처 및 근거

ORD 기록
ord-382b06ac20c74a1b8108fdcbcd7ddda9
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04705900

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