Sodium hydride → 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione

HRID 247613

반응식

HRID 247613 반응식
[H-].[Na+].[C:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:8]=1[OH:17])([CH3:6])([CH3:5])[CH3:4].[CH2:18]([N:36]1[C:40](=[O:41])[CH:39]=[CH:38][C:37]1=[O:42])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]>C(O)(C)(C)C>[C:13]([C:9]1[CH:10]=[C:11]([CH:39]2[CH2:38][C:37](=[O:42])[N:36]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[C:40]2=[O:41])[CH:12]=[C:7]([C:3]([CH3:6])([CH3:5])[CH3:4])[C:8]=1[OH:17])([CH3:16])([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 314052,6-Di-tert-butylphenolHCID 871181-octadecyl-1H-pyrrole-2,5-dione

생성물 1

HCID 141483763-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-n-octadecylpyrrolidine-2,5-dione수율 37%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

This compound is prepared by the procedure of Example 1 from 2.40 g (0.1 mol) of sodium hydride, 20.63 g (0.1 mol) of 2,6-di-tert-butylphenol, and 34.96 g (0.1 mole) of N-n-octadecylmaleimide in tert-butyl alcohol. The residue is purified by dry-column chromatography (3:1 heptane:ethyl acetate eluent) followed by recrystallization from petroleum ether to give 20.5 g (37%) of a white solid: mp 70°-73° C.

후처리

  1. customThe residue is purified by dry-column chromatography (3:1 heptane:ethyl acetate eluent)
  2. customfollowed by recrystallization from petroleum ether

출처 및 근거

ORD 기록
ord-bc9998d89c954ab68c5338046a6d93d4
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709050

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