Acetone → N-(3-methyl-4-hydroxybenzyl)acrylamide

HRID 247655

반응식

HRID 247655 반응식
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:9]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])O.Cl.CC(C)=O>O>[CH3:8][C:1]1[CH:2]=[C:3]([CH:4]=[CH:5][C:6]=1[OH:7])[CH2:9][NH:11][C:12](=[O:15])[CH:13]=[CH2:14]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 335O-CresolHCID 13543N-Methylolacrylamide

생성물 1

HCID 20160031N-(3-methyl-4-hydroxybenzyl)acrylamide수율 66.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A flask was charged with 108 g of o-cresol, 101 g of N-methylolacrylamide, 5 g of 37% aqueous hydrochloric acid solution and 100 ml of acetone, and the mixture was subjected to the condensation reaction at 60° C. for 60 minutes with stirring. The obtained reaction mixture was poured into excess water to separate an organic layer. The organic layer was dissolved in 200 ml of methylene chloride, which was washed with three 100 ml portions of water to give 127 g of N-(3-methyl-4-hydroxybenzyl)acrylamide.

후처리

  1. customthe mixture was subjected to the condensation reaction at 60° C. for 60 minutes
  2. customThe obtained reaction mixture
  3. customto separate an organic layer
  4. dissolutionThe organic layer was dissolved in 200 ml of methylene chloride
  5. washwhich was washed with three 100 ml portions of water

출처 및 근거

ORD 기록
ord-69e1e51af8ce4fe2be8d8ffb7ed1a3b9
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709062

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