Acetic Anhydride → (3-chlorophenyl)methyl Acetate

HRID 247727

반응식

HRID 247727 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1C=CC=CC=1>[C:10]([O:6][CH2:5][C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[CH:3]=1)(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 701173-Chlorobenzyl alcohol

생성물 1

HCID 11217649(3-chlorophenyl)methyl Acetate수율 96%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Into a solution of 84.4 g. (0.592 mole) of 3-chlorobenzyl alcohol in 40 cm3. of benzene 61.5 g. (0.6 mole) of acetic acid anhydride are dropped during 15 minutes while boiling. The reaction mixture is refluxed with 100 cm3. of benzene and washed with 100 cm3. of water thoroughly. The organic phase is separated and evaporated. 105.2 g. of 3-chlorobenzyl acetate are obtained which is suitable to ether-formation. nD20 : 1.5226, yield 96%.

후처리

  1. temperatureThe reaction mixture is refluxed with 100 cm3
  2. washof benzene and washed with 100 cm3
  3. customThe organic phase is separated
  4. customevaporated

출처 및 근거

ORD 기록
ord-0454e46b42c644bf8206535480ccf04b
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709081

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