Hydrochloric Acid → 2-Fluoro-4-n-tridecanoyloxybenzoic acid

HRID 247804

반응식

HRID 247804 반응식
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](Cl)(=[O:25])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].CN(C1C=CC=CN=1)C.Cl>ClCCl.C(N(CC)CC)C>[F:1][C:2]1[CH:10]=[C:9]([O:11][C:12](=[O:25])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 87288Tridecanoyl chlorideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

생성물 1

HCID 193652682-Fluoro-4-n-tridecanoyloxybenzoic acid수율 59.4%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

To a solution of 2-fluoro-4-hydroxybenzoic acid (1.4 g) and triethylamine (1.0 g) in dichloromethane (40 ml) were added tridecanoyl chloride (2.0 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours and thereto was added dilute aqueous hydrochloric acid solution. The organic layer was separated by a funnel and distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 1.8 g).

후처리

  1. customThe organic layer was separated by a funnel
  2. distillationdistilled
  3. customto remove the solvent
  4. washThe residue was washed with n-hexane
  5. customdried

출처 및 근거

ORD 기록
ord-01c87d2080664374a114683782c76fb9
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05207947

연결된 노트

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