Sodium Hydroxide → 2-[3-(Hydroxyimino)butyl]-1H-isoindole-1,3(2H)-dione

HRID 248763

반응식

HRID 248763 반응식
O=[C:2]([CH3:16])[CH2:3][CH2:4][N:5]1[C:9](=[O:10])[C:8]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:7]2[C:6]1=[O:15].Cl.[NH2:18][OH:19].[OH-].[Na+].C(=O)([O-])O.[Na+]>CO>[OH:19][N:18]=[C:2]([CH3:16])[CH2:3][CH2:4][N:5]1[C:9](=[O:10])[C:8]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:7]2[C:6]1=[O:15]

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 2907282-(3-Oxobutyl)isoindoline-1,3-dioneHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 714040032-[3-(Hydroxyimino)butyl]-1H-isoindole-1,3(2H)-dione수율 84.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.08 g (5.00 mmol) of N-(3-oxobutyl)phthalimide was dissolved in 10 ml of methanol and to the solution was added 0.695 g (10.0 mmol) of hydroxylamine hydrochloride. To this suspension was added 2 ml of 5N aqueous sodium hydroxide solution, followed by being stirred at room temperature for 16 hours. The reaction mixture was poured into 100 ml of saturated aqueous sodium hydrogencarbonate and extracted with chloroform (30 ml×3), and the combined organic layer was dried over magnesium sulfate. Chloroform was distilled off and the residual solids were washed with hexane to give 0.98 g (yield 84%) of the titled compound as colorless crystals.

후처리

  1. extractionextracted with chloroform (30 ml×3)
  2. dry with materialthe combined organic layer was dried over magnesium sulfate
  3. distillationChloroform was distilled off
  4. washthe residual solids were washed with hexane

출처 및 근거

ORD 기록
ord-f0c45504eaf34f9caf46112495a7d00c
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05211738

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