2-Amino-5-methylthiazole → HCID 22401741, 화합물

HRID 248881

반응식

HRID 248881 반응식
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[CH3:10][C:11]1[S:15][C:14]([NH2:16])=[N:13][CH:12]=1>C(#N)C>[BrH:1].[NH:16]=[C:14]1[N:13]([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)=[O:4])[CH:12]=[C:11]([CH3:10])[S:15]1

참가 물질

4

반응물 2

HCID 3517702-Amino-5-methylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

생성물 1

HCID 22401741HCID 22401741, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 51 parts of 2-bromo-1-(2-thienyl)ethanone, 28.5 parts of 5-methyl-2-thiazolamine and 240 parts of acetonitrile was stirred for 1 hour while heating on a waterbath. After cooling, the precipitate was filtered off, washed with ethanol and dried in vacuo, yielding 54 parts of 2-(2,3-dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide; mp. 207.5°-208° C. (interm. 56).

후처리

  1. temperaturewhile heating on a waterbath
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-ada5bbdbe62d4290905705d5d577da87
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212192

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