Hydrochloric Acid → 4,4'-Dichlorobenzhydrol

HRID 249166

반응식

HRID 249166 반응식
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)(C)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[OH:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 70344,4'-DichlorobenzophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 70334,4'-Dichlorobenzhydrol수율 98.8%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 4,4'-dichlorobenzophenone (2.51 g) in isopropyl alcohol (15 ml) was added sodium borohydride (0.45 g). The mixture was stirred for 4 hours at 50° C. and poured into diluted hydrochloric acid (60 ml). The organic layer was extracted with ethyl acetate (20 ml) and washed with water (30 ml×2). The solution was dried over magnesium sulfate. The solvent was removed in vacuo to give colorless oil of bis(4-chlorophenyl)methanol (2.50 g).

후처리

  1. extractionThe organic layer was extracted with ethyl acetate (20 ml)
  2. washwashed with water (30 ml×2)
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-1992318223c54782a559e8236f189c69
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212320

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