Hydrochloric Acid → 4,4'-Dichlorobenzhydrol
반응식
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)(C)C>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[OH:7])=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 4,4'-dichlorobenzophenone (2.51 g) in isopropyl alcohol (15 ml) was added sodium borohydride (0.45 g). The mixture was stirred for 4 hours at 50° C. and poured into diluted hydrochloric acid (60 ml). The organic layer was extracted with ethyl acetate (20 ml) and washed with water (30 ml×2). The solution was dried over magnesium sulfate. The solvent was removed in vacuo to give colorless oil of bis(4-chlorophenyl)methanol (2.50 g).
후처리
- extractionThe organic layer was extracted with ethyl acetate (20 ml)
- washwashed with water (30 ml×2)
- dry with materialThe solution was dried over magnesium sulfate
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-1992318223c54782a559e8236f189c69
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05212320
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