Hydrochloric Acid → 1-(4-Isobutylphenyl)hexan-1-ol

HRID 249184

반응식

HRID 249184 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:17])[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[BH4-].[Na+].Cl>CC(O)C>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([OH:17])[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 108790194'-Isobutylhexanophenone

생성물 1

HCID 109334301-(4-Isobutylphenyl)hexan-1-ol수율 88%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 4'-isobutylhexanophenone (10.5 g) in 2-propanol (60 ml) was added sodium borohydride (2.05 g), and the mixture was stirred at 50° C. for 6 hours. The mixture was poured into ice water and acidified with 6N hydrochloric acid. The aqueous solution was extracted with ethyl acetate and the combined organic layer was washed with water and brine, dried over magnesium sulfate and evaporated to give 1-(4-isobutylphenyl)hexan-1-ol (9.32 g) as a colorless oil.

후처리

  1. extractionThe aqueous solution was extracted with ethyl acetate
  2. washthe combined organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-3c9269b25b7b474dbd8fb82ea98e1513
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212320

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