2-Methylanisole → 4-Bromo-1-methoxy-2-methylbenzene

HRID 249279

반응식

HRID 249279 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:10][C:6]1[CH:5]=[CH:4][C:3]([O:8][CH3:9])=[C:2]([CH3:1])[CH:7]=1

참가 물질

5

반응물 2

HCID 336372-MethylanisoleHCID 67184N-bromobutanimide

생성물 1

HCID 6083154-Bromo-1-methoxy-2-methylbenzene수율 47.1%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

A solution of 24 g of 2-methylanisole, 35 g of N-bromosuccinimide and 1.24 g of dibenzoyl peroxide in 150 ml of carbon tetrachloride was heated to boiling under reflux for 12 hours. After cooling the solution was filtered and the filtrate is evaporated. The residue was recrystallized from hexane. There were obtained 18.6 g (47%) of 4-bromo-2-methylanisole as a colorless solid; m.p. 66°-68°.

후처리

  1. temperatureunder reflux for 12 hours
  2. temperatureAfter cooling the solution
  3. filtrationwas filtered
  4. customthe filtrate is evaporated
  5. customThe residue was recrystallized from hexane

출처 및 근거

ORD 기록
ord-e726e1f3800646a79b1e16dd269c2994
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05214046

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