4-Nitrobenzenesulfonyl chloride → N,N-dimethyl-4-nitrobenzenesulfonamide

HRID 24951

반응식

HRID 24951 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[CH3:15][NH:16][CH3:17].C(N(C(C)C)C)(C)C>ClCCl>[CH3:15][N:16]([CH3:17])[S:10]([C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)(=[O:12])=[O:11]

참가 물질

5

반응물 3

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 10473Dimethylamine, hydrochlorideHCID 547370N,N-Diisopropylmethylamine

생성물 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4.43 g (20 mmol) of 4-nitrobenzenesulphonic acid chloride are added dropwise at 0° C. to a solution of 2.45 g (30 mmol) of dimethylamine-hydrochloride and 6.46 g (50 mmol) of N,N-diisopropyl-N-methylamine in 30 ml of dichloromethane. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and dilute hydrochloric acid, dried over magnesium sulphate and evaporated to dryness.

후처리

  1. washThen the reaction solution is washed with water and dilute hydrochloric acid
  2. dry with materialdried over magnesium sulphate
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-fa275b5c963c420186aa69e2eb377b96
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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