Hydrochloric Acid → 4-Amino-5-cyano-2-hydroxybenzoic acid
반응식
[NH2:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([OH:15])[CH:3]=1.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:15])[CH:3]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
Ethyl 4-amino-5-cyano-2-hydroxybenzoate (3 g, 14.55 mmol) is treated with 60 ml of a 10% strength sodium hydroxide solution and the mixture is stirred at 50° C. for one hour. After cooling, the reaction solution is acidified with concentrated hydrochloric acid, diluted with water and the precipitate is filtered off with suction. The desired product is obtained after recrystallization from ethanol in 62% yield (1.6 g).
후처리
- temperatureAfter cooling
- filtrationthe precipitate is filtered off with suction
출처 및 근거
- ORD 기록
- ord-5010a193e6f04b1990b5337828cc718c
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863283B2
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