Guanidine → HCID 178510034, 화합물

HRID 25053

반응식

HRID 25053 반응식
[OH-].[Na+].[NH2:3][C:4]([NH2:6])=[NH:5].Cl[C:8]1[N:13]=[C:12]([CH2:14][C:15]2[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:22])[N:11]=[C:10]([NH:23][C:24]2[CH:31]=[CH:30][C:27]([C:28]#[N:29])=[CH:26][CH:25]=2)[N:9]=1>O1CCOCC1>[C:28]([C:27]1[CH:30]=[CH:31][C:24]([NH:23][C:10]2[N:11]=[C:12]([CH2:14][C:15]3[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:22])[N:13]=[C:8]([NH:5][C:4]([NH2:6])=[NH:3])[N:9]=2)=[CH:25][CH:26]=1)#[N:29]

참가 물질

5

반응물 3

HCID 3520GuanidineHCID 14798Sodium HydroxideHCID 4864234-[[4-Chloro-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]benzonitrile

생성물 1

HCID 178510034HCID 178510034, 화합물수율 64.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

NaOH (0.0128 mol), 1,4-dioxane (5 ml), and guanidine (0.0128 mol) were combined and stirred at RT for 5 minutes under argon. Then, intermediate (27) (0.00128 mol) was added and the reaction mixture was stirred at RT for 16 hours. The reaction mixture was quenched with H2O, and stirred. The resulting precipitate was filtered off and the residue was stirred in refluxing methanol, cooled, and filtered, yielding 0.34 g (64.3%) of N-[4-[(4-cyanophenyl)amino]-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]-guanidine (compound 20).

후처리

  1. stirringthe reaction mixture was stirred at RT for 16 hours
  2. customThe reaction mixture was quenched with H2O
  3. stirringstirred
  4. filtrationThe resulting precipitate was filtered off
  5. stirringthe residue was stirred
  6. temperaturein refluxing methanol
  7. temperaturecooled
  8. filtrationfiltered

출처 및 근거

ORD 기록
ord-46fa65e8e380434ab77bc22111932839
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858609B2

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