Hydrochloric Acid → 1-Ethylcyclobutane-1-carboxylic acid

HRID 250540

반응식

HRID 250540 반응식
[Li+].[CH3:2][CH:3]([N-]C(C)C)C.[CH:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1.ICC.Cl>C1COCC1>[CH2:2]([C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1)[CH3:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6340IodoethaneHCID 19494Cyclobutanecarboxylic acidHCID 2724682Lithium diisopropylamide

생성물 1

HCID 219960331-Ethylcyclobutane-1-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of LDA (100 ml; 2.0 M THF solution) in THF (100 ml) was added dropwise over a period of 20 minutes under cooling with ice, a solution of cyclobutane carboxylic acid (10 g, 0.1 mol) in THF (15 ml) and the mixture was stirred at RT for 2 h. To the mixture iodoethane (15.6 g, 0.1 mol) was added dropwise and the mixture was stirred at RT overnight. To the reaction mixture was added 2N HCl and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine to afford the title compound as a light yellow oil (22.4 g), which was used in the next step without purification.

후처리

  1. temperatureunder cooling with ice
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and brine

출처 및 근거

ORD 기록
ord-66d5b92fa14b4c4fbb1bb9983da0679b
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863312B2

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