N-bromobutanimide → 1-Benzyl-2-methyl-5-bromo-1H-imidazole

HRID 250743노트

반응식

HRID 250743 반응식
[Br:1]N1C(=O)CCC1=O.[CH2:9]([N:16]1[CH:20]=[CH:19][N:18]=[C:17]1[CH3:21])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)(Cl)Cl>[CH2:9]([N:16]1[C:20]([Br:1])=[CH:19][N:18]=[C:17]1[CH3:21])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 836991H-Imidazole, 2-methyl-1-(phenylmethyl)-

생성물 1

HCID 668687951-Benzyl-2-methyl-5-bromo-1H-imidazole수율 84.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Add N-bromosuccinimide (7.85 g, 44 mmol) to a solution of 1-benzyl-2-methyl-1H-imidazole (8.0 g, 46 mmol) in chloroform (200 mL) and stir for 6 hours. Wash reaction with saturated aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride, dry over magnesium sulfate, and filter through 2″ pad of silica gel. Concentrate filtrate reduced pressure. Suspend residue in diethyl ether (600 mL), heat to reflux and filter hot Concentrate ether filtrate under reduced pressure to give 9.3 g (37 mmol) of the desired compound as a tan solid.

후처리

  1. washWash
  2. customreaction with saturated aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride
  3. dry with materialdry over magnesium sulfate
  4. filtrationfilter through 2″ pad of silica gel
  5. temperatureSuspend residue in diethyl ether (600 mL), heat
  6. temperatureto reflux
  7. filtrationfilter hot
  8. concentrationConcentrate ether filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-f52250e3ee954fa7b57050bbb92284f4
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863310B2

반응 노트

불러오는 중…