Sodium Hydroxide → Quetiapine

HRID 251397

반응식

HRID 251397 반응식
C([O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=2)[CH2:12][CH2:11]1)(=O)C.[OH-].[Na+]>C(O)C>[CH:24]1[CH:25]=[CH:26][C:21]2[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=[C:16]([N:13]3[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][O:7][CH2:6][CH2:5][OH:4])[CH2:11][CH2:12]3)[C:22]=2[CH:23]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11487114Quetiapine acetate

생성물 1

HCID 5002Quetiapine수율 98.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The residue of 11-(4-[2-(2-acetyloxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine (7.8 g) was dissolved in ethanol (50 ml) and 1M NaOH solution (55 ml) was added. The mixture was stirred at room temperature for 30 min. The product was extracted into toluene (2×100 ml). Evaporation of the toluene phase gave quetiapine base (6.9 g).

후처리

  1. extractionThe product was extracted into toluene (2×100 ml)
  2. customEvaporation of the toluene phase

출처 및 근거

ORD 기록
ord-a5210979d7f94179863f210cad5b3ea0
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863441B2

연결된 노트

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