Hydrochloric Acid → 3-((4-(2-Fluorobenzyloxy)phenyl)-methylthio)propionic acid

HRID 251534

반응식

HRID 251534 반응식
[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][S:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][S:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21964542Ethyl 3-((4-(2-fluorobenzyloxy)phenyl)-methylthio)propionate

생성물 1

HCID 121322933-((4-(2-Fluorobenzyloxy)phenyl)-methylthio)propionic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of Ethyl 3-((4-(2-fluorobenzyloxy)phenyl)-methylthio)propionate (Step C, 0.122 g, 0.35 mmol) in ethanol (5 ml) was added 1N NaOH (0.5 ml) at room temperature. The reaction mixture was stirred for 3 hours, acidified with 1M HCl and concentrated in vacuo to give white solid which was purified by flash chromatography on silica gel column (chloroform:methanol, 92.5:7.5 spiked with acetic acid) to provide the title compound as a white solid.

후처리

  1. concentrationconcentrated in vacuo
  2. customto give white solid which
  3. customwas purified by flash chromatography on silica gel column (chloroform:methanol, 92.5:7.5 spiked with acetic acid)

출처 및 근거

ORD 기록
ord-4c20438b12974e509952f18393f29896
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863475B2

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