Water → 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole

HRID 25267

반응식

HRID 25267 반응식
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([CH3:21])[CH:15]=3)=[N:11][C:10]=2[CH:22]=1.C(N(CC)CC)C.O>C(Cl)(Cl)Cl>[F:5][C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:1](=[O:3])[CH3:2])=[C:16]([CH3:21])[CH:15]=3)=[N:11][C:10]=2[CH:22]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 3968134-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline

생성물 1

HCID 98827815-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Acetyl Chloride (0.09g, 1.55 mmol) was added to a solution of 5-fluoro2-(4′-amino-3′-methylphenyl)benzothiazole (0.2 g, 0.78 mmol) in chloroform (5 ml) containing triethylamine (86 mg, 0.85 mmol). The resulting solution was stirred for 30 min, then poured into water (20 ml). The organic layer was removed, dried (Na2SO4) and evaporated. Recrystallisation from ethanol gave a white solid.

후처리

  1. customThe organic layer was removed
  2. dry with materialdried (Na2SO4)
  3. customevaporated
  4. customRecrystallisation from ethanol
  5. customgave a white solid

출처 및 근거

ORD 기록
ord-ae5991969bc04edba7258ddf1b0edf6e
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858633B1

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