Sodium Hydroxide → 1-Methyl-1H-indole-6-carboxylic acid
반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([O:13]C)=[O:12])[CH:9]=2)[CH:4]=[CH:3]1.[OH-].[Na+]>CO.C1COCC1.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([OH:13])=[O:12])[CH:9]=2)[CH:4]=[CH:3]1참가 물질
4
실험 절차
Methyl 1-methyl-1H-indole-6-carboxylate 166 (1.24 mmol) was stirred with sodium hydroxide (0.59 g, 14.88 mmol) in a 2:2:1 mixture of methanol/THF/water (7.5 mL) for 36 hrs at rt to form a precipitate which was collected by filtration and lyophilized overnight to give the title compound 167 (0.54 g, 99% yield). MS: 175.06 (calc), 176.1 (obs).
후처리
- customto form a precipitate which
- filtrationwas collected by filtration
출처 및 근거
- ORD 기록
- ord-5902ff32a3db45d1bd8d0c87b9ee4246
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07868205B2
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