Sodium Hydroxide → 2-(2,6-diethyl-benzyl)-1H-imidazole

HRID 254529노트

반응식

HRID 254529 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[CH:11]([C:13]1[NH:14][CH:15]=[CH:16][N:17]=1)O)[CH3:2].[OH-].[Na+]>Cl.[Zn]>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[CH2:11][C:13]1[NH:14][CH:15]=[CH:16][N:17]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 58951693(2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol

생성물 1

HCID 247818692-(2,6-diethyl-benzyl)-1H-imidazole

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 313Hydrochloric Acid용매

실험 절차

To a solution of 90 mg (0.39 mmol) (2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol (Example 96) in 2 ml concentrated aqueous HCl solution were added 500 mg zinc foil and heated to reflux for 20 hours. Then the mixture was cooled to ambient temperature, aqueous sodium hydroxide solution added, the turbid solution filtered and the filtrate extracted with ethyl acetate. The combined extracts were washed with brine, dried over Na2SO4, filtered and evaporated. 2-(2,6-Diethyl-benzyl)-1H-imidazole was obtained as off-white solid: MS (EI): 214.3 (M+.).

후처리

  1. temperatureheated
  2. temperatureto reflux for 20 hours
  3. filtrationthe turbid solution filtered
  4. extractionthe filtrate extracted with ethyl acetate
  5. washThe combined extracts were washed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-33c18b7f7683461da07fc1f2e92cb67d
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875645B2

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