Iodine → HCID 66851890, 화합물

HRID 254628

반응식

HRID 254628 반응식
[NH2:1][CH2:2][C:3]1([OH:8])[CH2:7][CH2:6][CH2:5][CH2:4]1.[CH3:9][C:10]([CH3:15])([CH3:14])[CH2:11][CH:12]=O.[S-:16][C:17]#[N:18].[K+].II>C(#N)C>[C:10]([C:11]1[S:16][C:17](=[NH:18])[N:1]([CH2:2][C:3]2([OH:8])[CH2:7][CH2:6][CH2:5][CH2:4]2)[CH:12]=1)([CH3:15])([CH3:14])[CH3:9]

참가 물질

6

반응물 4

HCID 807IodineHCID 763353,3-DimethylbutanalHCID 516872Potassium thiocyanateHCID 130512021-(Aminomethyl)cyclopentan-1-ol

생성물 1

HCID 66851890HCID 66851890, 화합물수율 73.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-(aminomethyl)cyclopentanol (prepared from cyclopentanone as described in WO 2006/100208) (3.5 g, 30 mmol), 3,3-dimethylbutanal (3.4 g, 33 mmol), 4 Å molecular sieves (4 g, 8-12 mesh beads), potassium thiocyanate (3.9 g, 40 mmol) and iodine (7.7 g, 30 mmol) in acetonitrile (50 mL) were processed as described in Example 18A to provide the title compound (5.6 g, 22 mmol, 72% yield). MS (DCI/NH3) m/z 255 (M+H)+.

출처 및 근거

ORD 기록
ord-76dc9757d17c48a180e137e0db6aac40
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875640B2

연결된 노트

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