Hydrazine hydrate (1:1) → 3-(Morpholin-4-ylmethyl)aniline
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)([O-])=O.O.NN>C1COCC1.C(O)C.[Ni]>[N:8]1([CH2:7][C:6]2[CH:5]=[C:4]([NH2:1])[CH:16]=[CH:15][CH:14]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1참가 물질
5
실험 절차
To a solution of 4-(3-nitrobenzyl)morpholine (2.0 g; 9.0 mmol) in THF/ethanol mixture (1:1, 50 mL) was added a catalytical amount of Raney-Ni and hydrazine hydrate (36.0 mmol) and the mixture was stirred for 15 min at ambient temperature, filtered through a celite pad and the filtrate was evaporated to provide pure 3-morpholin-4-ylmethylphenylamine (2.03 g, 98%).
후처리
- filtrationfiltered through a celite pad
- customthe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-f2459027d6004a26b51c9599b18eba76
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07875728B2
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