Hydrochloric Acid → 4H-quinolizin-4-one-1,3-dicarboxylic acid

HRID 255600노트

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HRID 255600 반응식
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:17]([O:19]CC)=[O:18])[C:9](=[O:16])[N:10]2[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]2)=[O:5])C.[OH-].[Na+].Cl>CO>[C:6]1([C:4]([OH:5])=[O:3])[CH:7]=[C:8]([C:17]([OH:19])=[O:18])[C:9](=[O:16])[N:10]2[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 262620Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

생성물 1

HCID 139212454H-quinolizin-4-one-1,3-dicarboxylic acid수율 28%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
0 °C

실험 절차

To a solution of 1,3-diethoxycarbonyl-4H-quinolizin-4-one (896 mg) in methanol (9 ml) was added 6N aqueous sodium hydroxide (2.58 ml) at room temperature and the mixture was heated with reflux for an hour. After cooling to 0° C., the reaction mixture was acidified to pH 2 with 6N hydrochloric acid and the precipitate was filtered and washed with water to give 4H-quinolizin-4-one-1,3-dicarboxylic acid (202 mg).

후처리

  1. temperaturethe mixture was heated
  2. temperaturewith reflux for an hour
  3. filtrationthe precipitate was filtered
  4. washwashed with water

출처 및 근거

ORD 기록
ord-93a652526910429c87415cb6447a0262
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698349

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