N-bromobutanimide → 4-Bromomethyl-2-fluoropyridine

HRID 256171

반응식

HRID 256171 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[Br:9]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:9][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([F:1])[CH:7]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 27374032-Fluoro-4-methylpyridine

생성물 1

HCID 139851684-Bromomethyl-2-fluoropyridine수율 24.4%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

By the method of Example 20, 10 g (0.09 mole) of 2-fluoro-4-methylpyridine and 16 g (0.09 mole) of N-bromosuccinimide were reacted in 90 ml of carbon tetrachloride to produce 4.18 g 4-bromomethyl-2-fluoropyridine. The ir, proton nmr, and 19F nmr spectra were all consistent with the proposed structure.

출처 및 근거

ORD 기록
ord-34c5140a392d4dbeb1659ba46ee7b0da
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701464

연결된 노트

불러오는 중…