Acetonitrile → 1-Ethyl-4-(2-phenoxyethoxy)benzene

HRID 256244

반응식

HRID 256244 반응식
[C:1](#N)[CH3:2].[CH2:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[CH3:5].[OH-:13].[Na+]>CO.O>[O:13]([CH2:1][CH2:2][O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:4][CH3:5])=[CH:7][CH:8]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 312424-Ethylphenol

생성물 1

HCID 155969701-Ethyl-4-(2-phenoxyethoxy)benzene수율 98%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

Subsequently, 50 ml of acetonitrile, 0.092 mol of β-phenoxyethyl-p-tosylate, and 0.1 mol of p-ethylphenol were placed in a flask equipped with a stirrer. A 48 wt% aqueous solution of caustic soda (0.12 mol equivalent) was added dropwise at an inner temperature of not more than 75° C. while stirring. The mixture was stirred while refluxing for 2 hours. The reaction mixture was allowed to cool. On pouring the reaction mixture at about 40° C. into a methanol-water mixture, crystals precipitated. These crystals were separated by filtration, and then dried to yield 1-phenoxy-2-p-ethylphenoxyethane (m.p., 107°-108° C.). The yield was 98%.

후처리

  1. customequipped with a stirrer
  2. stirringThe mixture was stirred
  3. temperaturewhile refluxing for 2 hours
  4. temperatureto cool
  5. customprecipitated
  6. customThese crystals were separated by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-74722e027d9b46e289d2576dea01b735
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701565

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