Uridine → Ribavirin

HRID 256511

반응식

HRID 256511 반응식
[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.N1C=CN=N1.[C@@H:14]1(N2C=CC(=O)NC2=O)[O:22][C@H:19]([CH2:20][OH:21])[C@@H:17]([OH:18])[C@H:15]1[OH:16].[C@@H]1(N2C3N=CN=C(O)C=3N=C2)O[C@H](CO)[C@@H](O)[C@H]1O.[C@@H]1(N2C=CC(N)=NC2=O)O[C@H](CO)[C@@H](O)[C@H]1O.[C@@H]1(N2C3N=CN=C(N)C=3N=C2)O[C@H](CO)[C@@H](O)[C@H]1O.[C@@H]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H](CO)[C@@H](O)[C@H]1O.P([O-])(O)(O)=O.[K+]>>[CH:5]1[N:1]([C@@H:14]2[O:22][C@H:19]([CH2:20][OH:21])[C@@H:17]([OH:18])[C@H:15]2[OH:16])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

참가 물질

9

반응물 8

HCID 6029UridineHCID 6175CytidineHCID 60961AdenosineHCID 516951Monobasic potassium phosphateHCID 135398635GuanosineHCID 178418936HCID 178418936, 화합물HCID 178513825HCID 178513825, 화합물HCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

생성물 1

HCID 37542Ribavirin

실험 절차

By using a substrate solution (pH 6.0) containing 40 mM 1, 2, 4-triazole-3-carboxamide (hereinafter called "triazole") as the base donor, 40 mM uridine, inosine, cytidine, adenosine or guanosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, ribavirin was produced in the same manner as in Example 1. The results are shown in Table 7.

출처 및 근거

ORD 기록
ord-083540e260744b8b94717887f3bd53ce
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258301

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