Hydrochloric Acid → 1-Decyn-4-ol

HRID 256735노트

반응식

HRID 256735 반응식
Cl[C:2](=[CH2:12])[CH2:3][CH:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[OH:5].[OH-].[Na+].Cl>CN(C)C=O>[CH2:6]([CH:4]([CH2:3][C:2]#[CH:12])[OH:5])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11030613HCID 11030613, 화합물

생성물 1

HCID 5441861-Decyn-4-ol수율 97%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

20.00 Grams of the 2-chloroallyl-n-hexylcarbinol obtained above were dissolved in 200 g of N,N-dimethylformamide, and 8.39 g of sodium hydroxide in a flake form were added. The resultant mixture was stirred at 25° C. for 10 hours. After the reaction was completed the reaction mixture was neutralized with concentrated hydrochloric acid, and insolubles were filtered off. After the filtrate was concentrated under reduced pressure, the concentration residue was subjected to extraction with toluene, washed with a 7% sodium carbonate aqueous solution and then dried over sodium sulfate. The desiccant was filtered off, and the toluene was distilled off. The resultant oily substance was distilled under reduced pressure to give 15.70 g of n-hexylpropargylcarbinol. The results were as follows.

후처리

  1. filtrationwere filtered off
  2. concentrationAfter the filtrate was concentrated under reduced pressure
  3. extractionthe concentration residue was subjected to extraction with toluene
  4. washwashed with a 7% sodium carbonate aqueous solution
  5. dry with materialdried over sodium sulfate
  6. filtrationThe desiccant was filtered off
  7. distillationthe toluene was distilled off
  8. distillationThe resultant oily substance was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-2d95b47f0c38412a96f6c67693b06f61
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258529

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