Sodium Hydroxide → 2-((Benzyloxy)methyl)morpholine

HRID 257278

반응식

HRID 257278 반응식
S(O)([O:4][CH2:5][CH2:6][NH2:7])(=O)=O.[OH-].[Na+].[CH2:11]([O:18][CH2:19][CH:20]1[CH2:22]O1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[CH2:11]([O:18][CH2:19][CH:20]1[O:4][CH2:5][CH2:6][NH:7][CH2:22]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 14798Sodium Hydroxide2회HCID 70223Aminoethyl sulfateHCID 94247Benzyl glycidyl ether

생성물 1

HCID 136700222-((Benzyloxy)methyl)morpholine

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

199 g of 2-aminoethyl hydrogen sulfate are added to 164 ml of 70% sodium hydroxide solution, the solution is heated to 50° C. and added dropwise to a solution of (RS)-benzyloxymethyloxirane in 280 ml of methanol. After 1 hour at 50° C. a further 280 ml of 70% sodium hydroxide solution are added thereto and the solution is stirred overnight. Then, the reaction mixture is poured on to ice and extracted with toluene. The organic phase is washed with water, dried and evaporated. After distillation there are obtained 26.8 g of rac-2-benzyloxymethylmorpholine, MS: M+ -91=116 (benzyl).

후처리

  1. additionThen, the reaction mixture is poured on to ice
  2. extractionextracted with toluene
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated
  6. distillationAfter distillation

출처 및 근거

ORD 기록
ord-1e506a4d26304ae08c89fe3fcd0bbae1
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260307

연결된 노트

불러오는 중…