Ammonia → 4-Amino-3-nitropyridine

HRID 257422

반응식

HRID 257422 반응식
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1Cl)([O-:3])=[O:2].C([O-])(=O)C.[NH4+:15].N>>[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH2:15])([O-:3])=[O:2]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 517165Ammonium AcetateHCID 27357814-Chloro-3-nitropyridine

생성물 1

HCID 5488034-Amino-3-nitropyridine수율 59%

반응 조건

온도
135 °C

실험 절차

Five grams (31.5 mmol) of 3-nitro-4-chloropyridine was mixed with 26 g of ammonium acetate, and the mixture was heated at 130-140° C. for 3 hours. The mixture was allowed to cool, and then adjusted to pH 10 with concentrated aqueous ammonia. The precipitated powder was collected by filtration to obtain 2.6 g of the intended yield: 59%).

후처리

  1. temperatureto cool
  2. filtrationThe precipitated powder was collected by filtration
  3. customto obtain 2.6 g of the intended yield: 59%)

출처 및 근거

ORD 기록
ord-346aaf12786f4e2591f295f5d73eca29
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262415

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