Iodoethane → 1-Phenyl-3-(3-n-propyl-4-pyridyl)butane

HRID 257474

반응식

HRID 257474 반응식
[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH3:17])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:18](I)[CH3:19].[Li].C(NC(C)C)(C)C>>[C:1]1([CH2:7][CH2:8][CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH3:19])[CH3:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 3

HCID 6340IodoethaneHCID 197832971-Phenyl-3-(3-methyl-4-pyridyl)butaneHCID 45051747Lithium diisopropylamine

생성물 1

HCID 197833201-Phenyl-3-(3-n-propyl-4-pyridyl)butane수율 15.6%

실험 절차

2.1 g (9.35 mmol) of 1-phenyl-3-(3-methyl-4-pyridyl)butane, 1.46 g (9.35 mmol) of ethyl iodide and 2 equivalent of lithium-diisopropylamine were reacted in the same manner as in Example 1. The reaction product was purified to obtain 0.37 g of the desired compound (yield: 15.6%).

후처리

  1. customThe reaction product was purified

출처 및 근거

ORD 기록
ord-050c0500979a4433a4718a4be18e859c
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262420

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