Hydrochloric Acid → HCID 19092324, 화합물

HRID 257767노트

반응식

HRID 257767 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:16]([O:18][CH2:19][CH3:20])=[O:17].Cl>[OH-].[Na+]>[CH2:19]([O:18][C:16]([NH:1][C:2]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])=[O:17])[CH3:20]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10928Ethyl chloroformateHCID 190923252-Amino-4-sulfamoylbenzoic acid

생성물 1

HCID 19092324HCID 19092324, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매2회

실험 절차

To a solution of 2-amino-4-sulfamoylbenzoic acid (1.32 g) in 2N sodium hydroxide (6 ml) was added dropwise ethyl chloroformate (1.9 ml) and 2N sodium hydroxide on an ice bath. After stirring for 3 hours, the reaction mixture was acidified with 1N hydrochloric acid, extracted with ethyl acetate. Combined organic extracts were washed in turn with water and brine, dried over magnesium sulfate and evaporated to give an amorphous of 2-ethoxycarbonylamino-4-sulfamoylbenzoic acid (1.99 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washCombined organic extracts were washed in turn with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-5572a17979674af897811a7f66d172a3
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05264438

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