Water → 3-(3-(4-Pentenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

HRID 257894

반응식

HRID 257894 반응식
[CH2:1]([OH:6])[CH2:2][CH2:3][CH:4]=[CH2:5].[H-].[Na+].Cl[C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1.O>O1CCCC1>[CH2:1]([O:6][C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1)[CH2:2][CH2:3][CH:4]=[CH2:5]

참가 물질

6

반응물 4

HCID 962WaterHCID 131814-Penten-1-OLHCID 24758Sodium hydrideHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

생성물 1

HCID 190753593-(3-(4-Pentenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 4-penten-1-ol (640 mg, 7.5 mmol) and sodium hydride (260 mg, 7.5 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

후처리

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-6569828db04d4d729de71e9bfb39bfb9
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05264444

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