Ethyl Acetoacetate → 3-Acetyl-7-methoxycoumarin

HRID 25873

반응식

HRID 25873 반응식
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:12](OCC)(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15]>N1CCCCC1>[C:14]([C:13]1[C:12](=[O:17])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][CH:7]=[C:8]([O:10][CH3:11])[CH:9]=2)(=[O:15])[CH3:16]

참가 물질

4

반응물 2

HCID 8868Ethyl AcetoacetateHCID 696002-Hydroxy-4-Methoxybenzaldehyde

생성물 1

HCID 20544753-Acetyl-7-methoxycoumarin

시약·촉매·용매 1

HCID 8082Piperidine촉매

실험 절차

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

후처리

  1. temperaturewas warmed on a hot plate until solution
  2. temperatureto be heated gently
  3. waitAfter several minutes the reaction mixture solidified
  4. temperatureAfter cooling
  5. customthe product was recrystallized from a mixture of alcohol and acetonitrile

출처 및 근거

ORD 기록
ord-0dc7f5bd4b6b41e582a9b7b4128509d7
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147552

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