Methanol → 1,3-Bis(2-hydroxyethylthio)propane

The sodium mercaptide of 2-mercaptoethanol was made by reacting 1 mole each of sodium methoxide and 2-mercaptoethanol in dry methanol under a nitrogen atmosphere. To this solution, 0.5 mole of 1,3-dichloropropane was added and the mixture was refluxed for 1 hour and filtered. The methanol filtrate was evaporated on a flash evaporator and traces of 2-mercaptoethanol were distilled off at high vacuum at room temperature. The yellow, oily residue was extracted with acetone, the solution filtered, and the acetone evaporated to give a 95 percent yield of the crude product.

1. temperaturethe mixture was refluxed for 1 hour
2. filtrationfiltered
3. customThe methanol filtrate was evaporated on a flash evaporator and traces of 2-mercaptoethanol
4. distillationwere distilled off at high vacuum at room temperature
5. extractionThe yellow, oily residue was extracted with acetone
6. filtrationthe solution filtered
7. customthe acetone evaporated

ORD 기록

ord-b8a27b8a1a794ffebfedb31a6d6eee9a

출처 데이터셋

uspto-grants-1977_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

USRE029305