Acetic Acid → 6-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide

HRID 259174

반응식

HRID 259174 반응식
C(O)(=[O:3])C.[O:5]([CH2:12][C:13]([NH:15][CH:16]1[C:27](=[O:28])[N:18]2[CH:19]([C:24]([OH:26])=[O:25])[C:20]([CH3:23])([CH3:22])[S:21][C@H:17]12)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C([O-])([O-])=O.C([O-])([O-])=O.OO.OO.OO.[Na+].[Na+].[Na+].[Na+].Cl>O.O.[O-][W]([O-])(=O)=O.[Na+].[Na+].O>[O:5]([CH2:12][C:13]([NH:15][CH:16]1[C:27](=[O:28])[N:18]2[CH:19]([C:24]([OH:26])=[O:25])[C:20]([CH3:23])([CH3:22])[S:21](=[O:3])[C@H:17]12)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 159762Sodium percarbonateHCID 123738936-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid

생성물 1

HCID 122939416-(2-Phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide

시약·촉매·용매 2

HCID 150191Sodium Tungstate Dihydrate촉매HCID 962Water용매2회

실험 절차

Acetic acid (10 cc) was added to 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid (1.75 g.), and sodium percarbonate (1.89 g.) was added thereto at 10° - 15° C. To the mixture were added water (2 cc) and sodium tungstate dihydrate (120 mg.), and the mixture was stirred for 2 hours. The mixture was acidified to a pH 3 with water (50 cc) and 10% hydrochloric acid. The precipitate was collected by filtration, washed with water and dried to yield crude crystals (1.31 g.) of 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide, m.p. 160° - 161° C.

후처리

  1. additionwas added
  2. customat 10° - 15° C
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-dc4567c89c3548648cfa0299df9f4c2e
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04036847

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