Sodium Hydroxide → 3-Tert-butyl-2-methoxybenzoic acid

HRID 259578

반응식

HRID 259578 반응식
[C:1]([C:5]1[C:6]([O:12][CH3:13])=[C:7]([CH3:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[Mn]([O-])(=O)(=O)=[O:15].[K+].[OH-:20].[Na+]>>[C:1]([C:5]1[C:6]([O:12][CH3:13])=[C:7]([CH:8]=[CH:9][CH:10]=1)[C:11]([OH:15])=[O:20])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 516875Potassium Permanganate2회HCID 521940Benzene, 1-(1,1-dimethylethyl)-2-methoxy-3-methyl-

생성물 1

HCID 156915293-Tert-butyl-2-methoxybenzoic acid

실험 절차

A mixture of 0.01 mole of 3-t-butyl-2-methoxytoluene, 0.01 mole of potassium permanganate, and 100 ml. of 1 N sodium hydroxide solution is heated to reflux and another 0.01 mole of potassium permanganate is added each hour until a total of 0.05 mole has been added (4 hours). After another 2 hours of reflux the unreacted starting material is steam distilled. Ethanol is added to the residue to decompose excess permanganate and mixture is filtered hot. Acidification with sulfuric acid of the filtrate causes precipitation of the product which is collected, washed with water and dried to give 3-t-butyl-2-methoxybenzoic acid.

후처리

  1. temperatureto reflux
  2. additionhas been added (4 hours)
  3. temperatureAfter another 2 hours of reflux the
  4. distillationdistilled
  5. additionEthanol is added to the residue
  6. filtrationis filtered hot
  7. customprecipitation of the product which
  8. customis collected
  9. washwashed with water
  10. customdried

출처 및 근거

ORD 기록
ord-f452fd2f998a4f7288c30dd803c0df99
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038396

연결된 노트

불러오는 중…