4-Chlorophenol → 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one

HRID 25965

반응식

HRID 25965 반응식
Br[CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1.[Na]>C(OCC)(=O)C.C(O)C>[C:9]1([CH:2]([O:22][C:19]2[CH:20]=[CH:21][C:16]([Cl:15])=[CH:17][CH:18]=2)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

6

반응물 3

HCID 46844-ChlorophenolHCID 5360545SodiumHCID 134586931-Bromo-3,3-dimethyl-1-phenylbutan-2-one

생성물 1

HCID 213260281-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one수율 67%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 25.4 g (0.1 mole) of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one in 50 ml of ethyl acetate was added dropwise, at the boil, to a solution of 12.85 g (0.1 mole) of 4-chlorophenol and 2.3 g (0.1 mole) of sodium in 100 ml of ethanol. After boiling for 12 hours under reflux, the sodium bromide which had separated out was filtered off hot. The filtrate was distilled in vacuo and the solid residue which remained was recrystallized from ligroin. 20.2 g (67% of theory) of 1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one of melting point 103° C. were obtained.

후처리

  1. temperatureunder reflux
  2. customthe sodium bromide which had separated out
  3. filtrationwas filtered off hot
  4. distillationThe filtrate was distilled in vacuo
  5. customthe solid residue which remained was recrystallized from ligroin

출처 및 근거

ORD 기록
ord-2a6191e666fa47fc92c5b3dc0bd416f8
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147791

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