Hydrochloric Acid → 4-chloro-N,2-dihydroxybenzamide
반응식
Cl.[NH2:2][OH:3].C[O-].[Na+].[Cl:7][C:8]1[CH:9]=[C:10]([OH:18])[C:11](=[CH:16][CH:17]=1)[C:12](OC)=[O:13].Cl>CO>[Cl:7][C:8]1[CH:9]=[C:10]([OH:18])[C:11](=[CH:16][CH:17]=1)[C:12]([NH:2][OH:3])=[O:13]참가 물질
6
실험 절차
Hydroxylamine hydrochloride (20.65 g, 0.297 mol) is added to a mixture of sodium methoxide (53 g, 0.99 mol) in methanol while maintaining the temperature below 10° C. A mixture of methyl 4-chlorosalicylate (46.2 g, 0.248 mol) in methanol is then added to the reaction mixture and the resultant mixture is stirred at room temperature for 10 days, acidified with concentrated hydrochloric acid (pH3) and filtered to give the title product as an off-white solid which is identified by NMR spectral analyses.
후처리
- temperaturewhile maintaining the temperature below 10° C
- additionis then added to the reaction mixture
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-89b5131461cb4552905ee45876d6a515
- 출처 데이터셋
- uspto-grants-1996_06
- 특허 번호
- US05523278
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