Formamide → 5-chloro-6-methyl-1H-pyrimidin-4-one

HRID 259806

반응식

HRID 259806 반응식
[NH2:1][C:2]([CH3:9])=[C:3]([Cl:8])[C:4](OC)=[O:5].[CH:10]([NH2:12])=O.C[O-].[Na+]>CO>[Cl:8][C:3]1[C:4]([OH:5])=[N:12][CH:10]=[N:1][C:2]=1[CH3:9]

참가 물질

5

반응물 3

HCID 713FormamideHCID 10942334Sodium MethoxideHCID 76224675Methyl 3-amino-2-chloro-2-butenoate

생성물 1

HCID 1784332125-chloro-6-methyl-1H-pyrimidin-4-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

25.9 g (0.17 mol) of methyl 3-amino-2-chloro-2-butenoate are reacted with 11.7 g (0.26 mol) of formamide and 51 ml of sodium methylate solution in 20 ml of methanol and worked up in analogy to Example 9 (reaction time 20 h). Yield: 16.6 g (67.5%)

후처리

  1. customworked up in analogy to Example 9 (reaction time 20 h)

출처 및 근거

ORD 기록
ord-58ad2a4fdb2f4d9bb1f83c2c5786fa1f
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523404

연결된 노트

불러오는 중…