반응식
[CH3:1][CH:2]([C:16]([OH:18])=[O:17])[C:3]1[CH:4]=[CH:5][C:6]([C:10]2[CH:11]=[CH:12]C=CC=2)=[C:7](F)[CH:8]=1.[CH2:19](O)C>>[OH:18][C:16]([CH:2]([C:3]1[CH:8]=[CH:7][C:6]([CH2:10][CH:11]([CH3:12])[CH3:19])=[CH:5][CH:4]=1)[CH3:1])=[O:17]참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
Three grams of flurbiprofen and 30 g of poloxamer 237 were heated at 110° C. for 10 minutes to obtain a liquified mixture and cooled to 60° C. Into this mixture, 5 g of polyethylene glycol 300, 10 g of ethanol and 52 g of pH 4 buffer solution were added at 60° C. to obtain an ibuprofen gel.
후처리
- customto obtain a liquified mixture
출처 및 근거
- ORD 기록
- ord-b0ad4fad120e4b30b6d002e81134c3db
- 출처 데이터셋
- uspto-grants-1996_06
- 특허 번호
- US05527832
연결된 노트
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